High-performance liquid chromatographic determination of penicillamine in whole blood, plasma, and urine.

نویسندگان

  • R F Bergstrom
  • D R Kay
  • J G Wagner
چکیده

A high-performance liquid chromatographic method for the determination of penicillamine in plasma, whole blood, and urine samples is described. The method uses a commercially available electrochemical detector at a potential of +0.1 V versus the Ag/AgCl reference electrode. This method is selective and sensitive for sulfhydryl compounds. The chromatography separates penicillamine from other endogenous sulfhydryl compounds with a limit of detection for penicillamine in biological samples of ca. 10(07) M.

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عنوان ژورنال:
  • Journal of chromatography

دوره 222 3  شماره 

صفحات  -

تاریخ انتشار 1981